Garcia Research Group

Protein Folding/unfolding: pressure effects

The main objective of this project is to establish the relationship between the thermodynamics and the structural properties of pressure induced changes in proteins using molecular simulations. Pressure provides a way of shifting equilibrium of protein configurations without increasing thermal fluctuations or changing the system composition. This work will establish a framework for understanding the role of water in protein function and stability, as well as for the interpretation of a number of experimental studies of pressure effects on biological molecules. This work is funded by NSF MCB-0543769 and MCB-1050966.

Selected Publications:

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